The Centre for the Studies of Asphyxia and Resuscitation

From bench to bedside: translating physiology into clinical trials Cardiopulmonary resuscitation (CPR) at birth remains one of the most critical—and challenging—situations in neonatal care. While only a small proportion of newborns require CPR, the outcomes are sobering: mortality remains high, and survivors often face significant neurological injury. This blog highlights an important journey in neonatal resuscitation research— the development and translation of chest compres

Providing effective and gentle respiratory support in the first minutes after birth is one of the most critical—and challenging—tasks in neonatal care. The VOLT trial (Volume-Targeted mask ventilation versus pressure ventilation in preterm infants) was designed to address a fundamental gap in delivery room practice: how to reliably deliver safe tidal volumes during positive pressure ventilation (PPV) immediately after birth. Why does this matter? When preterm infants fail to

Vasopressin vs Epinephrine during cardiopulmonary resuscitation of asphyxiated newborns – a cluster randomized controlled phase I trial Introduction Current neonatal resuscitation guidelines recommend the use of epinephrine during neonatal cardiopulmonary resuscitation (CPR). However, newborns receiving epinephrine continue to have high rates of mortality and neurodevelopmental disability. The infrequent need for neonatal CPR, coupled with an inability to consistently anticip

Leading the Way in Newborn Resuscitation Research Behind every major clinical trial is a dedicated team of experts guiding the vision,...

The Data Safety Monitoring Board (DSMB) reviewed the data after 400 patients were enrolled at least 28 days old, to assess the safety of...