Upcoming Randomized Controlled Trials
This page highlights randomized controlled trials that are in development or preparing to launch, led by or involving the Centre for the Studies of Asphyxia and Resuscitation (CSAR) through Research4Babies.org. These upcoming studies are in advanced stages of protocol development, regulatory and ethics approval, site preparation, or funding review. They reflect CSAR’s ongoing commitment to addressing important evidence gaps in neonatal care and to advancing innovative, physiology-driven research. As these trials progress, details will be updated and studies will move to active recruitment once enrollment begins.
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If you or your site is interested in joining any of CSAR’s current neonatal clinical trials, or if you are leading a neonatal trial and would like CSAR to participate as a study site, please contact Dr. Schmölzer directly at schmolze@ualberta.ca
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RESAIR3-Trial: 21% vs 100% initial Oxygen concentration for term newborns
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The SPLASH Trial: Surfactant Prophylaxis in LAte preterm to early term infants using a Supraglottic airway device to Help improve outcomes
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The HULC-2-Trial: A randomized double-blind, placebo controlled multi-centre trial of Mesenchymal Stromal Cells (MSCs) in extreme preterm infants at risk of developing Bronchopulmonary Dysplasia – A Phase 2 Study
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The SPIN-Trial: Single dose Prophylactic INdomethacin in extremely preterm infants – A Randomized Blinded Placebo-Controlled Superiority Trial
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The MicroVENT-Trial: Respiratory support with High-Frequency Jet Ventilation vs. High-Frequency Oscillatory Ventilation in Micropremie infants
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The PROTECT-HIE Pilot Trial: Prophylactic Therapy to Enhance Cardiovascular Treatment in Neonatal Hypoxemic Ischemic Encephalopathy